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	<title>TechCombo &#187; Paul Young</title>
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	<link>http://techcombo.com</link>
	<description>Technology, Health and News</description>
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		<title>MicroRNA-205 for the Treatment and Diagnosis of Parkinson Disease</title>
		<link>http://techcombo.com/2011/09/14/microrna-205-for-the-treatment-and-diagnosis-of-parkinson-disease-123/</link>
		<comments>http://techcombo.com/2011/09/14/microrna-205-for-the-treatment-and-diagnosis-of-parkinson-disease-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:54 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/microrna-205-for-the-treatment-and-diagnosis-of-parkinson-disease-123/</guid>
		<description><![CDATA[Parkinson disease (PD) is a devastating neurodegenerative movement disorder, pathologically characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of intracytoplasmic inclusions named Lewy bodies and Lewy neurites (Schapira, Baillieres Clin. Neurol. 6:15-36, 1997). Increasing numbers of genes have been identified as a genetic cause of PD (Hardy et al., Ann. Neurol. 60:389-398, 2006), for example, multiple missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene were recently found to be associated with an autosomal dominant form of familial PD (Paisan-Ruiz et al., Neuron 44:595-600, 2004; Zimprich et al., Neuron 44:601-607, 2004; Zabetian et al., Neurology 65:741-744, 2005). Recent genome-wide association studies (GWAS) also revealed LRRK2, together with SNCA (encoding alpha-syn) and PARK16, as shared risk loci for PD (Simon-Sanchez et al., Nat. Genet. 41:1308-1312, 2009; Satake et al., Nat. Genet. 41:1303-1307, 2009), indicating a potential contribution of normal LRRK2 protein to the etiology of sporadic PD cases. Micro-RNAs (miRNAs or miRs) are evolutionarily conserved small non-protein coding transcripts that bind to partially complementary binding sites in the 3? untranslated region (3?-UTR) of target messenger RNAs (mRNAs) and control the translation of their target mRNAs at the post-transcriptional level (Bartel, [...]]]></description>
			<content:encoded><![CDATA[<p><in-context-comment:auto-on><br />
Parkinson disease (PD) is a devastating neurodegenerative movement disorder, pathologically characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of intracytoplasmic inclusions named Lewy bodies and Lewy neurites (Schapira, Baillieres Clin. Neurol. 6:15-36, 1997).<in-context-comment:here:definition> Increasing numbers of genes have been identified as a genetic cause of PD (Hardy et al., Ann. Neurol. 60:389-398, 2006), for example, multiple missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene were recently found to be associated with an autosomal dominant form of familial PD (Paisan-Ruiz et al., Neuron 44:595-600, 2004; Zimprich et al., Neuron 44:601-607, 2004; Zabetian et al., Neurology 65:741-744, 2005). Recent genome-wide association studies (GWAS) also revealed LRRK2, together with SNCA (encoding alpha-syn) and PARK16, as shared risk loci for PD (Simon-Sanchez et al., Nat. Genet. 41:1308-1312, 2009; Satake et al., Nat. Genet. 41:1303-1307, 2009), indicating a potential contribution of normal LRRK2 protein to the etiology of sporadic PD cases.</p>
<p>Micro-RNAs (miRNAs or miRs) are evolutionarily conserved small non-protein coding transcripts that bind to partially complementary binding sites in the 3? untranslated region (3?-UTR) of target messenger RNAs (mRNAs) and control the translation of their target mRNAs at the post-transcriptional level (Bartel, Cell 116:281-297, 2004). Several miRNAs have been associated with neurodegenerative disease as well as synaptic plasticity, memory formation and developmental cell fate decisions in the nervous system (Hebert and De Strooper, Trends Neurosci. 32:199-206, 2009; Kosik, Nat. Rev. Neurosci. 7:911-920, 2006).</p>
<p>NIH inventors have recently discovered that LRRK2 protein expression is significantly increased in the brain of PD patients, while expression of miR-205 is specifically down-regulated in the same patients. Also, the NIH inventors have discovered that the expression levels of LRRK2 and miR-205 are dynamically regulated and reversely correlated in multiple brain regions and at different ages in mouse brains, indicating that miR-205 plays a regulatory role in LRRK2 protein expression.</p>
<p>Based on these novel findings, the present technology provides for novel methods of treatment of patients suffering from PD disease by modulating the amount of miR-205 in patients by administration of a miR-205 gene product, a vector encoding a miR-205 gene product or an agent that increases expression of miR-205. The present technology also provides for methods of determining the effectiveness of different candidate drugs for the treatment of PD, methods of diagnosing PD, or having an increased susceptibility to developing PD, and an in vitro process for identifying a therapeutic agent for the treatment of PD.</p>
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		<item>
		<title>Novel Osteobiologic Proteins for Treatment of Osteoporosis, Rheumatoid and Neurologic Diseases</title>
		<link>http://techcombo.com/2011/09/14/novel-osteobiologic-proteins-for-treatment-of-osteoporosis-rheumatoid-and-neurologic-diseases-4-123/</link>
		<comments>http://techcombo.com/2011/09/14/novel-osteobiologic-proteins-for-treatment-of-osteoporosis-rheumatoid-and-neurologic-diseases-4-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:53 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/novel-osteobiologic-proteins-for-treatment-of-osteoporosis-rheumatoid-and-neurologic-diseases-4-123/</guid>
		<description><![CDATA[In an effort to find effective strategies for treatment of body tissue and structural damage as the result of trauma, cancer and other diseases, scientists at the Food and Drug Administration (FDA) have identified Cartilage-Derived Morphogenetic Proteins (CDMP) and associated pathways instrumental in replacing or regenerating damaged tissue. These proteins have unique activities likely to be useful as stand alone agents or in construction of engineered tissues. CDMPs appear helpful in the healing of bone and joint surface lesions, and also for the repair or reconstruction of cartilaginous tissues, tendons and ligaments. The invention identifies proteins belonging to TGF-Beta superfamily that promote repair of menisci, cruciate and collateral ligaments of the knee, and rotator cuff tendons. The patent application claims nucleic acids encoding human Cartilage-Derived Morphogenetic Protein-1 (hCDMP-1) variant polypeptides. Morphogenetic proteins are able to induce the proliferation and differentiation of progenitor cells into functional bone, cartilage, tendon, or ligament tissue.]]></description>
			<content:encoded><![CDATA[<p>In an effort to find effective strategies for treatment of body tissue and structural damage as the result of trauma, cancer and other diseases, scientists at the Food and Drug Administration (FDA) have identified Cartilage-Derived Morphogenetic Proteins (CDMP) and associated pathways instrumental in replacing or regenerating damaged tissue.  These proteins have unique activities likely to be useful as stand alone agents or in construction of engineered tissues.</p>
<p>CDMPs appear helpful in the healing of bone and joint surface lesions, and also for the repair or reconstruction of cartilaginous tissues, tendons and ligaments.  The invention identifies proteins belonging to TGF-Beta superfamily that promote repair of menisci, cruciate and collateral ligaments of the knee, and rotator cuff tendons.  The patent application claims nucleic acids encoding human Cartilage-Derived Morphogenetic Protein-1 (hCDMP-1) variant polypeptides.  Morphogenetic proteins are able to induce the proliferation and differentiation of progenitor cells into functional bone, cartilage, tendon, or ligament tissue.</p>
]]></content:encoded>
			<wfw:commentRss>http://techcombo.com/2011/09/14/novel-osteobiologic-proteins-for-treatment-of-osteoporosis-rheumatoid-and-neurologic-diseases-4-123/feed/</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Novel Methods for the Reversible Incorporation of Functional Groups into RNA and DNA:  Synthesis and Uses for 2?-O-aminooxymethyl Nucleoside Derivatives</title>
		<link>http://techcombo.com/2011/09/14/novel-methods-for-the-reversible-incorporation-of-functional-groups-into-rna-and-dna-synthesis-and-uses-for-2-o-aminooxymethyl-nucleoside-derivatives-123/</link>
		<comments>http://techcombo.com/2011/09/14/novel-methods-for-the-reversible-incorporation-of-functional-groups-into-rna-and-dna-synthesis-and-uses-for-2-o-aminooxymethyl-nucleoside-derivatives-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:51 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/novel-methods-for-the-reversible-incorporation-of-functional-groups-into-rna-and-dna-synthesis-and-uses-for-2-o-aminooxymethyl-nucleoside-derivatives-123/</guid>
		<description><![CDATA[The delivery of DNA/RNA therapeutic drugs is still a major hurdle for the clinical application of DNA/RNA-based drugs. Also, developments in silencing the expression of specific genes, through RNA interference pathways, have led to an increased demand for synthetic RNA sequences and have created a pressing need for rapid and efficient methods for RNA synthesis. Recently, FDA scientists have developed a novel phosphoramidite, 2?-O-aminooxymethyl ribonucleoside (2?-O-protected compounds). The 2?-O-aminooxymethyl ribonucleoside can be modified with any type of functional group using an oximation reaction as long as the functional group contains an aldehyde, ketone, or acetal group. Modification of the 2?-O-aminooxymethyl with an aldehyde results in a conjugated 2?-phosphoramidite that could be readily converted back to the native ribonucleoside and its corresponding by-product. On the other hand, the oximation of 2?-O-aminooxymethy with a ketone results in an irreversible conjugated form of the phosphoramidite. The 2?-O-protected compounds of the present technology have several advantages, for example, the 2?-O-protected compound is stable during the various reaction steps involved in oligonucleotide synthesis; and the protecting group can be easily removed after the synthesis of the oligonucleotide, for example, by reaction with tetrabutylammonium fluoride; and the O-protected groups do not generate DNA/RNA alkylating side products, [...]]]></description>
			<content:encoded><![CDATA[<p>The delivery of DNA/RNA therapeutic drugs is still a major hurdle for the clinical application of DNA/RNA-based drugs. Also, developments in silencing the expression of specific genes, through RNA interference pathways, have led to an increased demand for synthetic RNA sequences and have created a pressing need for rapid and efficient methods for RNA synthesis.  Recently, FDA scientists have developed a novel phosphoramidite, 2?-O-aminooxymethyl ribonucleoside (2?-O-protected compounds).  The 2?-O-aminooxymethyl ribonucleoside can be modified with any type of functional group using an oximation reaction as long as the functional group contains an aldehyde, ketone, or acetal group.  Modification of the 2?-O-aminooxymethyl with an aldehyde results in a conjugated 2?-phosphoramidite that could be readily converted back to the native ribonucleoside and its corresponding by-product.  On the other hand, the oximation of 2?-O-aminooxymethy with a ketone results in an irreversible conjugated form of the phosphoramidite.</p>
<p>The 2?-O-protected compounds of the present technology have several advantages, for example, the 2?-O-protected compound is stable during the various reaction steps involved in oligonucleotide synthesis; and the protecting group can be easily removed after the synthesis of the oligonucleotide, for example, by reaction with tetrabutylammonium fluoride; and the O-protected groups do not generate DNA/RNA alkylating side products, which have been reported during removal of 2?-O-(2-cyanoethyl)oxymethyl or 2?-O-[2-(4-tolylsulfonyl)ethoxymethyl groups under similar conditions.</p>
]]></content:encoded>
			<wfw:commentRss>http://techcombo.com/2011/09/14/novel-methods-for-the-reversible-incorporation-of-functional-groups-into-rna-and-dna-synthesis-and-uses-for-2-o-aminooxymethyl-nucleoside-derivatives-123/feed/</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>The Human Nuclear Co-Repressor Gene:  Applications for Cancer Diagnostics/Therapeutics and Gene Expression Research</title>
		<link>http://techcombo.com/2011/09/14/the-human-nuclear-co-repressor-gene-applications-for-cancer-diagnosticstherapeutics-and-gene-expression-research-123/</link>
		<comments>http://techcombo.com/2011/09/14/the-human-nuclear-co-repressor-gene-applications-for-cancer-diagnosticstherapeutics-and-gene-expression-research-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:49 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/the-human-nuclear-co-repressor-gene-applications-for-cancer-diagnosticstherapeutics-and-gene-expression-research-123/</guid>
		<description><![CDATA[The human nuclear receptor co-repressor (huN-CoR) forms multimolecular complexes that alters chromatin structure, resulting in disrupted gene expression. The huN-CoR complex is central to normal processes such as erythropoiesis and thymocyte development, but is also linked to multiple cancers including colorectal carcinomas, endometrial cancers and leukemia, particularly acute myeloid leukemia. Thus, huN-CoR is a potentially-valuable tool for cancer diagnosis, as well as a target for the development of huN-CoR-based cancer therapeutics. HuN-CoR is also an attractive research tool for the study of gene regulation, epigenetic modification and gene silencing. The technology claims nucleic acid sequences comprising the huN-CoR gene and fragments thereof, as well as a gene chip array incorporating such fragments.]]></description>
			<content:encoded><![CDATA[<p>The human nuclear receptor co-repressor (huN-CoR) forms multimolecular complexes that alters chromatin structure, resulting in disrupted gene expression.  The huN-CoR complex is central to normal processes such as erythropoiesis and thymocyte development, but is also linked to multiple cancers including colorectal carcinomas, endometrial cancers and leukemia, particularly acute myeloid leukemia.  Thus, huN-CoR is a potentially-valuable tool for cancer diagnosis, as well as a target for the development of huN-CoR-based cancer therapeutics.  HuN-CoR is also an attractive research tool for the study of gene regulation, epigenetic modification and gene silencing.</p>
<p>The technology claims nucleic acid sequences comprising the huN-CoR gene and fragments thereof, as well as a gene chip array incorporating such fragments.</p>
]]></content:encoded>
			<wfw:commentRss>http://techcombo.com/2011/09/14/the-human-nuclear-co-repressor-gene-applications-for-cancer-diagnosticstherapeutics-and-gene-expression-research-123/feed/</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Production of Adeno-Associated Viruses in Insect Cells</title>
		<link>http://techcombo.com/2011/09/14/production-of-adeno-associated-viruses-in-insect-cells-123/</link>
		<comments>http://techcombo.com/2011/09/14/production-of-adeno-associated-viruses-in-insect-cells-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:47 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/production-of-adeno-associated-viruses-in-insect-cells-123/</guid>
		<description><![CDATA[Adeno-associated virus (AAV) is being developed for gene therapy applications. This virus type presents several advantages over alternate vectors for therapeutic gene delivery. AAV is not considered pathogenic and transduces stably dividing and non-dividing cells. AAV also shows good serotype specificity to various cell types for targeted gene delivery. The present invention describes a highly scalable adeno-associated virus (AAV) vector production method in insect cells. The system for producing recombinant AAV (rAAV) uses the AAV Rep protein and an AAV ITR. This production method produces virus particles much more efficiently than the standard mammalian cell culture system. Yields of rAAV produced in Sf9 cells exceed 10e15 per liter for some constructs. The improvement in production efficiency translates into lower production costs and potential for commercial scale manufacturing. In addition, all serotypes of AAV can be produced, with the respective AAV serotype vectors available for the immediate scale up of AAV production. This technology will give a company producing large quantities of AAV a significant competitive advantage over traditional AAV production methods.]]></description>
			<content:encoded><![CDATA[<p>Adeno-associated virus (AAV) is being developed for gene therapy applications.  This virus type presents several advantages over alternate vectors for therapeutic gene delivery.  AAV is not considered pathogenic and transduces stably dividing and non-dividing cells.  AAV also shows good serotype specificity to various cell types for targeted gene delivery.</p>
<p>The present invention describes a highly scalable adeno-associated virus (AAV) vector production method in insect cells.  The system for producing recombinant AAV (rAAV) uses the AAV Rep protein and an AAV ITR.  This production method produces virus particles much more efficiently than the standard mammalian cell culture system.  Yields of rAAV produced in Sf9 cells exceed 10e15 per liter for some constructs.  The improvement in production efficiency translates into lower production costs and potential for commercial scale manufacturing.  In addition, all serotypes of AAV can be produced, with the respective AAV serotype vectors available for the immediate scale up of AAV production.</p>
<p>This technology will give a company producing large quantities of AAV a significant competitive advantage over traditional AAV production methods.</p>
]]></content:encoded>
			<wfw:commentRss>http://techcombo.com/2011/09/14/production-of-adeno-associated-viruses-in-insect-cells-123/feed/</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Modulation of Leucine-rich Repeats and Calponin Homology Domain-containing Protein 4 (Lrch4) Activity for Therapeutic Applications</title>
		<link>http://techcombo.com/2011/09/14/modulation-of-leucine-rich-repeats-and-calponin-homology-domain-containing-protein-4-lrch4-activity-for-therapeutic-applications-123/</link>
		<comments>http://techcombo.com/2011/09/14/modulation-of-leucine-rich-repeats-and-calponin-homology-domain-containing-protein-4-lrch4-activity-for-therapeutic-applications-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:46 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/modulation-of-leucine-rich-repeats-and-calponin-homology-domain-containing-protein-4-lrch4-activity-for-therapeutic-applications-123/</guid>
		<description><![CDATA[NIH Inventors have recently discovered a novel Leucine-rich repeat and calponin homology domain-containing protein 4 (Lrch4) in a proteomic screen of the plasma membrane of lipopolysaccharide (LPS)-exposed macrophages. Expression data by RT-PCR revealed that all Lrch family members (1-4) are expressed in macrophages, but only Lrch4 was recruited into lipid rafts (signaling microdomains of the plasma membrane) by LPS. Lrch4 is the most highly expressed Lrch family member in mouse tissues. It is a predicted single-spanning transmembrane protein that is encoded by the Lrch4 gene in humans. The Lrch4 ectodomain is predicted to have a series of leucine-rich repeats, the motifs by which Toll like Receptors (TLR) are thought to bind microbial ligands. The human form of Lrch4 is 83% identical to murine Lrch4 and is predicted to have 680 amino acids and a molecular weight of 73 kDa. NIH inventors have shown that Lrch4 is expressed on the plasma membrane of macrophages. They have determined that Lrch4 regulates pro-inflammatory signals (NF-kappaB activation, cytokine induction) emanating from all TLRs tested, and also regulates ligand-independent signals from MyD88. Further, LPS-induced p38, JNK, and NFkappaB activation are attenuated following Lrch4 knockdown, indicating that Lrch4 regulates upstream LPS signaling events. LPS-induced expression of [...]]]></description>
			<content:encoded><![CDATA[<p>NIH Inventors have recently discovered a novel Leucine-rich repeat and calponin homology domain-containing protein 4 (Lrch4) in a proteomic screen of the plasma membrane of lipopolysaccharide (LPS)-exposed macrophages.  Expression data by RT-PCR revealed that all Lrch family members (1-4) are expressed in macrophages, but only Lrch4 was recruited into lipid rafts (signaling microdomains of the plasma membrane) by LPS.  Lrch4 is the most highly expressed Lrch family member in mouse tissues.  It is a predicted single-spanning transmembrane protein that is encoded by the Lrch4 gene in humans.  The Lrch4 ectodomain is predicted to have a series of leucine-rich repeats, the motifs by which Toll like Receptors (TLR) are thought to bind microbial ligands.  The human form of Lrch4 is 83% identical to murine Lrch4 and is predicted to have 680 amino acids and  a molecular weight of 73 kDa.</p>
<p>NIH inventors have shown that Lrch4 is expressed on the plasma membrane of macrophages.  They have determined that Lrch4 regulates pro-inflammatory signals (NF-kappaB activation, cytokine induction) emanating from all TLRs tested, and also regulates ligand-independent signals from MyD88.  Further, LPS-induced p38, JNK, and NFkappaB activation are attenuated following Lrch4 knockdown, indicating that Lrch4 regulates upstream LPS signaling events.  LPS-induced expression of the NF-kappaB-dependent cytokine TNFalpha was attenuated following Lrch4 knockdown at the level of both transcript and protein.  Based on these and other findings, the inventors of this technology propose that Lrch4 may be a novel component of TLR receptor complexes and that modulation of Lrch4 activity might open up new opportunities for developing novel therapeutics for inflammatory diseases.</p>
]]></content:encoded>
			<wfw:commentRss>http://techcombo.com/2011/09/14/modulation-of-leucine-rich-repeats-and-calponin-homology-domain-containing-protein-4-lrch4-activity-for-therapeutic-applications-123/feed/</wfw:commentRss>
		<slash:comments>0</slash:comments>
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		<item>
		<title>Identification of EGFR as A Receptor for AAV6 Transduction</title>
		<link>http://techcombo.com/2011/09/14/identification-of-egfr-as-a-receptor-for-aav6-transduction-123/</link>
		<comments>http://techcombo.com/2011/09/14/identification-of-egfr-as-a-receptor-for-aav6-transduction-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 18:27:43 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/14/identification-of-egfr-as-a-receptor-for-aav6-transduction-123/</guid>
		<description><![CDATA[AAV vectors offer unique advantages in gene therapy applications. Studies have shown that these replication deficient parvovirus vectors can deliver DNA to specific tissues and confer long-term transgene expression in a variety of systems. Although many studies have looked at the tissue-specific expression elicited by each of the AAV serotypes, a true understanding of how AAV transduces these tissues is still unclear. Of the large AAV family, only a few receptors or co-receptors have been identified. The ability to better target transduction to specific tissues on the basis of the receptors that each serotype uses for entry is essential for selecting a serotype given the receptor expression in specific tissue, or to exploit altered receptor expression under disease conditions. AAV6 has been reported to effectively transduce muscle, lung, brain, and multiple types of tumors, including gliomas and lung adenocarcinomas. By using a bioinformatics based screen approach, the NIH investigators discovered that the epidermal growth factor receptor (EGFR) is a co-receptor for AAV6 infection in mammalian cells, and is necessary for efficient vector internalization.]]></description>
			<content:encoded><![CDATA[<p>AAV vectors offer unique advantages in gene therapy applications.  Studies have shown that these replication deficient parvovirus vectors can deliver DNA to specific tissues and confer long-term transgene expression in a variety of systems.  Although many studies have looked at the tissue-specific expression elicited by each of the AAV serotypes, a true understanding of how AAV transduces these tissues is still unclear.  Of the large AAV family, only a few receptors or co-receptors have been identified.  The ability to better target transduction to specific tissues on the basis of the receptors that each serotype uses for entry is essential for selecting a serotype given the receptor expression in specific tissue, or to exploit altered receptor expression under disease conditions.</p>
<p>AAV6 has been reported to effectively transduce muscle, lung, brain, and multiple types of tumors, including gliomas and lung adenocarcinomas.  By using a bioinformatics based screen approach, the NIH investigators discovered that the epidermal growth factor receptor (EGFR) is a co-receptor for AAV6 infection in mammalian cells, and is necessary for efficient vector internalization.</p>
]]></content:encoded>
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		<slash:comments>0</slash:comments>
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		<item>
		<title>Avedro Acquires Patent Portfolio for Breakthrough Transepithelial Riboflavin</title>
		<link>http://techcombo.com/2011/09/13/avedro-acquires-patent-portfolio-for-breakthrough-transepithelial-riboflavin-123/</link>
		<comments>http://techcombo.com/2011/09/13/avedro-acquires-patent-portfolio-for-breakthrough-transepithelial-riboflavin-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 06:52:43 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/13/avedro-acquires-patent-portfolio-for-breakthrough-transepithelial-riboflavin-123/</guid>
		<description><![CDATA[WALTHAM, Mass.&#8211;NEWS&#8211;Avedro acquires patents for transepithelial cross-linking]]></description>
			<content:encoded><![CDATA[<p>WALTHAM, Mass.&#8211;NEWS&#8211;Avedro acquires patents for transepithelial cross-linking<br clear="both" style="clear: both;"/><br />
<br clear="both" style="clear: both;"/><br />
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<br /><b>Related Hot Topics</b><br /><ul><li><a href="http://nccam.nih.gov/news/2012/020312.htm?nav=rss"target="_new" title="NCCAM's Advisory Council Welcomes Six New Members" >NCCAM&#8217;s Advisory Council Welcomes Six New Members</a></li></ul><div style="margin-left: 40px;"><p>The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health.</p></div><ul><li><a href="http://nccam.nih.gov/news/2012/020212.htm?nav=rss"target="_new" title="In the News: Resveratrol" >In the News: Resveratrol</a></li></ul><div style="margin-left: 40px;"><p>Resveratrol is a naturally occurring chemical found in red wine and other plant products and is sometimes sold as a dietary supplement. Recently, a study funded by the National Heart, Lung, and Blood Institute looked at how resveratrol works at the cellular level, identifying how it may provide its health benefits.</p></div><ul><li><a href="http://nccam.nih.gov/news/2012/011012.htm?nav=rss"target="_new" title="In the News: Placebo Effect" >In the News: Placebo Effect</a></li></ul><div style="margin-left: 40px;"><p>Recently, several news outlets have been highlighting research studies of the placebo effect. The placebo response can be defined as the benefit patients receive from a treatment that has no active components. Researchers are using innovative study designs to untangle the complexities of the placebo effect.</p></div><ul><li><a href="http://nccam.nih.gov/research/results/spotlight/110411.htm?nav=rss"target="_new" title="Soy Protein Supplements Do Not Reduce Plaque in Arteries of Postmenopausal Women" >Soy Protein Supplements Do Not Reduce Plaque in Arteries of Postmenopausal Women</a></li></ul><div style="margin-left: 40px;"><p>Soy protein supplements containing isoflavones do not significantly reduce the progression of atherosclerosis (build-up of plaque in the arteries) in postmenopausal women, according to a recent study published in the journal <cite>Stroke</cite>. However, a subgroup analysis of this study showed that soy supplements may benefit women who had experienced menopause within the last 5 years. Isoflavones are compounds similar to the female hormone estrogen and act like estrogen in some tissues. Previous epidemiological and laboratory research has suggested that isoflavones extracted from soybeans may have cardioprotective effects and may be a safe therapeutic alternative to hormone therapy for postmenopausal women. </p></div><ul><li><a href="http://nccam.nih.gov/about/offices/od/director.htm?nav=rss"target="_new" title="Message from the Director: New Directions" >Message from the Director: New Directions</a></li></ul><div style="margin-left: 40px;"><p>The need for careful research on complementary and alternative health practices remains compelling. Tens of millions of Americans are spending $34 billion per year (mostly out-of-pocket) on a variety of complementary approaches, most often without any solid evidence about safety or usefulness.
</p><p>
The opportunities to make real differences in some very challenging health issues are equally compelling. After a decade of mainly exploratory research across a broad array of interventions, practices, products, and disciplines, emerging scientific evidence points toward the need for more targeted investment in selected complementary approaches.</p></div><ul><li><a href="http://nccam.nih.gov/health/safety/?nav=rss"target="_new" title="Safe Use of Complementary Health Products and Practices" >Safe Use of Complementary Health Products and Practices</a></li></ul><div style="margin-left: 40px;"><p>As with any treatment, it is important to consider safety before using complementary health products and practices. Safety depends on the specific therapy, and each complementary product or practice should be considered on its own.
</p><p>
Mind and body practices such as meditation and yoga, for example, are generally considered to be safe in healthy people when practiced appropriately. Natural products such as herbal medicines or botanicals are often sold as dietary supplements and are readily available to consumers; however, there is a lot we don�t know about the safety of many of these products, in part because a manufacturer does not have to prove the safety and effectiveness of a dietary supplement before it is available to the public.</p></div><ul><li><a href="http://nccam.nih.gov/health/providers/digest/depression.htm?nav=rss"target="_new" title="Depression and Complementary Health Practices" >Depression and Complementary Health Practices</a></li></ul><div style="margin-left: 40px;"><p>Depression is a medical condition that affects nearly 21 million American adults each year, according to the National Institute of Mental Health. Mood, thoughts, physical health, and behavior all may be affected. Among the common symptoms of depression are persistent sad, anxious, or &#34;empty&#34; feelings; feelings of hopelessness, guilt, and/or worthlessness; restlessness or irritability; fatigue; difficulty concentrating; insomnia; overeating, or loss of appetite; and/or thoughts of suicide.
</p><p>
Many people with a depressive illness never seek treatment. But the majority, even those with the most severe depression, can get better with treatment. Depression can be treated effectively with conventional medicine, including antidepressants and certain types of psychotherapy.
</p><p>
Some people turn to complementary health products and practices for depression, including the dietary supplement St. John&#8217;s wort; however, no complementary approach has been proven effective for the long-term treatment of depression. This issue provides information on &#34;what the science says&#34; about the effects of complementary health products for depression, including the dietary supplements omega-3 fatty acids, St. John&#8217;s wort, valerian, as well as other complementary practices such as massage, relaxation techniques, and yoga.</p></div><ul><li><a href="http://nccam.nih.gov/health/probiotics/?nav=rss"target="_new" title="Probiotics" >Probiotics</a></li></ul><div style="margin-left: 40px;"><p>Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called &#34;friendly bacteria&#34; or &#34;good bacteria.&#34; Probiotics are available to consumers mainly in the form of dietary supplements and foods.</p></div><ul><li><a href="http://nccam.nih.gov/health/pain/headaches.htm?nav=rss"target="_new" title="Headaches and CAM" >Headaches and CAM</a></li></ul><div style="margin-left: 40px;"><p>Headaches are one of the most common forms of pain. For some people a headache may be a minor irritation once or twice a year, while others can suffer disabling pain on an almost daily basis. Researchers are studying treatments for different types of headaches, including a number of complementary and alternative medicine (CAM) therapies. This fact sheet provides basic information on headaches, summarizes research on the effectiveness and safety of selected complementary and alternative practices for headaches, and suggests sources for additional information. If you are considering a complementary and alternative therapy for headaches, this information can help you talk to your health care provider about it.</p></div><ul><li><a href="http://nccam.nih.gov/health/stjohnswort/ataglance.htm?nav=rss"target="_new" title="St. John's Wort" >St. John&#8217;s Wort</a></li></ul><div style="margin-left: 40px;"><p>St. John&#39;s wort is a plant with yellow flowers whose medicinal uses were first recorded in ancient Greece. The flowering tops of St. John&#39;s wort are used to prepare teas, tablets, and capsules containing concentrated extracts. Liquid extracts and topical preparations are also used. Today, St. John&#39;s wort is used by some for depression, anxiety, and/or sleep disorders.</p></div>
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		<title>Axeq Technologies Announces Comprehensive Copy Number Variant and Breakpoint Determination Services Coupled with New Whole-Genome Sequencing Programs</title>
		<link>http://techcombo.com/2011/09/13/axeq-technologies-announces-comprehensive-copy-number-variant-and-breakpoint-determination-services-coupled-with-new-whole-genome-sequencing-programs-123/</link>
		<comments>http://techcombo.com/2011/09/13/axeq-technologies-announces-comprehensive-copy-number-variant-and-breakpoint-determination-services-coupled-with-new-whole-genome-sequencing-programs-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 06:52:40 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

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		<description><![CDATA[ROCKVILLE, Md.&#8211;NEWS&#8211;Axeq launched copy number variation &#038; breakpoint determination capabilities coupled with whole genome sequencing services. This method offers the most comprehensive estimates of personal CNVs to date.]]></description>
			<content:encoded><![CDATA[<p>ROCKVILLE, Md.&#8211;NEWS&#8211;Axeq launched copy number variation &#038; breakpoint determination capabilities coupled with whole genome sequencing services. This method offers the most comprehensive estimates of personal CNVs to date.<br clear="both" style="clear: both;"/><br />
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<br /><b>Related Hot Topics</b><br /><ul><li><a href="http://nccam.nih.gov/news/2012/020312.htm?nav=rss"target="_new" title="NCCAM's Advisory Council Welcomes Six New Members" >NCCAM&#8217;s Advisory Council Welcomes Six New Members</a></li></ul><div style="margin-left: 40px;"><p>The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health.</p></div><ul><li><a href="http://nccam.nih.gov/news/2012/020212.htm?nav=rss"target="_new" title="In the News: Resveratrol" >In the News: Resveratrol</a></li></ul><div style="margin-left: 40px;"><p>Resveratrol is a naturally occurring chemical found in red wine and other plant products and is sometimes sold as a dietary supplement. Recently, a study funded by the National Heart, Lung, and Blood Institute looked at how resveratrol works at the cellular level, identifying how it may provide its health benefits.</p></div><ul><li><a href="http://nccam.nih.gov/news/2012/011012.htm?nav=rss"target="_new" title="In the News: Placebo Effect" >In the News: Placebo Effect</a></li></ul><div style="margin-left: 40px;"><p>Recently, several news outlets have been highlighting research studies of the placebo effect. The placebo response can be defined as the benefit patients receive from a treatment that has no active components. Researchers are using innovative study designs to untangle the complexities of the placebo effect.</p></div><ul><li><a href="http://nccam.nih.gov/research/results/spotlight/110411.htm?nav=rss"target="_new" title="Soy Protein Supplements Do Not Reduce Plaque in Arteries of Postmenopausal Women" >Soy Protein Supplements Do Not Reduce Plaque in Arteries of Postmenopausal Women</a></li></ul><div style="margin-left: 40px;"><p>Soy protein supplements containing isoflavones do not significantly reduce the progression of atherosclerosis (build-up of plaque in the arteries) in postmenopausal women, according to a recent study published in the journal <cite>Stroke</cite>. However, a subgroup analysis of this study showed that soy supplements may benefit women who had experienced menopause within the last 5 years. Isoflavones are compounds similar to the female hormone estrogen and act like estrogen in some tissues. Previous epidemiological and laboratory research has suggested that isoflavones extracted from soybeans may have cardioprotective effects and may be a safe therapeutic alternative to hormone therapy for postmenopausal women. </p></div><ul><li><a href="http://nccam.nih.gov/about/offices/od/director.htm?nav=rss"target="_new" title="Message from the Director: New Directions" >Message from the Director: New Directions</a></li></ul><div style="margin-left: 40px;"><p>The need for careful research on complementary and alternative health practices remains compelling. Tens of millions of Americans are spending $34 billion per year (mostly out-of-pocket) on a variety of complementary approaches, most often without any solid evidence about safety or usefulness.
</p><p>
The opportunities to make real differences in some very challenging health issues are equally compelling. After a decade of mainly exploratory research across a broad array of interventions, practices, products, and disciplines, emerging scientific evidence points toward the need for more targeted investment in selected complementary approaches.</p></div><ul><li><a href="http://nccam.nih.gov/health/safety/?nav=rss"target="_new" title="Safe Use of Complementary Health Products and Practices" >Safe Use of Complementary Health Products and Practices</a></li></ul><div style="margin-left: 40px;"><p>As with any treatment, it is important to consider safety before using complementary health products and practices. Safety depends on the specific therapy, and each complementary product or practice should be considered on its own.
</p><p>
Mind and body practices such as meditation and yoga, for example, are generally considered to be safe in healthy people when practiced appropriately. Natural products such as herbal medicines or botanicals are often sold as dietary supplements and are readily available to consumers; however, there is a lot we don�t know about the safety of many of these products, in part because a manufacturer does not have to prove the safety and effectiveness of a dietary supplement before it is available to the public.</p></div><ul><li><a href="http://nccam.nih.gov/health/providers/digest/depression.htm?nav=rss"target="_new" title="Depression and Complementary Health Practices" >Depression and Complementary Health Practices</a></li></ul><div style="margin-left: 40px;"><p>Depression is a medical condition that affects nearly 21 million American adults each year, according to the National Institute of Mental Health. Mood, thoughts, physical health, and behavior all may be affected. Among the common symptoms of depression are persistent sad, anxious, or &#34;empty&#34; feelings; feelings of hopelessness, guilt, and/or worthlessness; restlessness or irritability; fatigue; difficulty concentrating; insomnia; overeating, or loss of appetite; and/or thoughts of suicide.
</p><p>
Many people with a depressive illness never seek treatment. But the majority, even those with the most severe depression, can get better with treatment. Depression can be treated effectively with conventional medicine, including antidepressants and certain types of psychotherapy.
</p><p>
Some people turn to complementary health products and practices for depression, including the dietary supplement St. John&#8217;s wort; however, no complementary approach has been proven effective for the long-term treatment of depression. This issue provides information on &#34;what the science says&#34; about the effects of complementary health products for depression, including the dietary supplements omega-3 fatty acids, St. John&#8217;s wort, valerian, as well as other complementary practices such as massage, relaxation techniques, and yoga.</p></div><ul><li><a href="http://nccam.nih.gov/health/probiotics/?nav=rss"target="_new" title="Probiotics" >Probiotics</a></li></ul><div style="margin-left: 40px;"><p>Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called &#34;friendly bacteria&#34; or &#34;good bacteria.&#34; Probiotics are available to consumers mainly in the form of dietary supplements and foods.</p></div><ul><li><a href="http://nccam.nih.gov/health/pain/headaches.htm?nav=rss"target="_new" title="Headaches and CAM" >Headaches and CAM</a></li></ul><div style="margin-left: 40px;"><p>Headaches are one of the most common forms of pain. For some people a headache may be a minor irritation once or twice a year, while others can suffer disabling pain on an almost daily basis. Researchers are studying treatments for different types of headaches, including a number of complementary and alternative medicine (CAM) therapies. This fact sheet provides basic information on headaches, summarizes research on the effectiveness and safety of selected complementary and alternative practices for headaches, and suggests sources for additional information. If you are considering a complementary and alternative therapy for headaches, this information can help you talk to your health care provider about it.</p></div><ul><li><a href="http://nccam.nih.gov/health/stjohnswort/ataglance.htm?nav=rss"target="_new" title="St. John's Wort" >St. John&#8217;s Wort</a></li></ul><div style="margin-left: 40px;"><p>St. John&#39;s wort is a plant with yellow flowers whose medicinal uses were first recorded in ancient Greece. The flowering tops of St. John&#39;s wort are used to prepare teas, tablets, and capsules containing concentrated extracts. Liquid extracts and topical preparations are also used. Today, St. John&#39;s wort is used by some for depression, anxiety, and/or sleep disorders.</p></div>
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		<title>Pharmaron to Host Merck Serono Research and Development Laboratory in China</title>
		<link>http://techcombo.com/2011/09/13/pharmaron-to-host-merck-serono-research-and-development-laboratory-in-china-123/</link>
		<comments>http://techcombo.com/2011/09/13/pharmaron-to-host-merck-serono-research-and-development-laboratory-in-china-123/#comments</comments>
		<pubDate>Wed, 14 Sep 2011 06:52:36 +0000</pubDate>
		<dc:creator>Paul Young</dc:creator>
				<category><![CDATA[Health]]></category>

		<guid isPermaLink="false">http://techcombo.com/2011/09/13/pharmaron-to-host-merck-serono-research-and-development-laboratory-in-china-123/</guid>
		<description><![CDATA[BEIJING&#8211;NEWS&#8211;Pharmaron announced a strategic partnership with Merck Serono, the biopharmaceutical division of Merck KGaA, Germany. In the framework of this partnership, Pharmaron’s new campus in the Beijing Economic and Technological Development Area (BDA) will serve as home to Merck Serono’s China R&#038;D Laboratory. The focus of this laboratory will be clinical bioanalysis and biomarker characterization, allowing for the identification of gene mutations among the Chinese populatio]]></description>
			<content:encoded><![CDATA[<p>BEIJING&#8211;NEWS&#8211;Pharmaron announced a strategic partnership with Merck Serono, the biopharmaceutical division of Merck KGaA, Germany. In the framework of this partnership, Pharmaron’s new campus in the Beijing Economic and Technological Development Area (BDA) will serve as home to Merck Serono’s China R&#038;D Laboratory. The focus of this laboratory will be clinical bioanalysis and biomarker characterization, allowing for the identification of gene mutations among the Chinese populatio<br clear="both" style="clear: both;"/><br />
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<br /><b>Related Hot Topics</b><br /><ul><li><a href="http://nccam.nih.gov/news/2012/020312.htm?nav=rss"target="_new" title="NCCAM's Advisory Council Welcomes Six New Members" >NCCAM&#8217;s Advisory Council Welcomes Six New Members</a></li></ul><div style="margin-left: 40px;"><p>The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health.</p></div><ul><li><a href="http://nccam.nih.gov/news/2012/020212.htm?nav=rss"target="_new" title="In the News: Resveratrol" >In the News: Resveratrol</a></li></ul><div style="margin-left: 40px;"><p>Resveratrol is a naturally occurring chemical found in red wine and other plant products and is sometimes sold as a dietary supplement. Recently, a study funded by the National Heart, Lung, and Blood Institute looked at how resveratrol works at the cellular level, identifying how it may provide its health benefits.</p></div><ul><li><a href="http://nccam.nih.gov/news/2012/011012.htm?nav=rss"target="_new" title="In the News: Placebo Effect" >In the News: Placebo Effect</a></li></ul><div style="margin-left: 40px;"><p>Recently, several news outlets have been highlighting research studies of the placebo effect. The placebo response can be defined as the benefit patients receive from a treatment that has no active components. Researchers are using innovative study designs to untangle the complexities of the placebo effect.</p></div><ul><li><a href="http://nccam.nih.gov/research/results/spotlight/110411.htm?nav=rss"target="_new" title="Soy Protein Supplements Do Not Reduce Plaque in Arteries of Postmenopausal Women" >Soy Protein Supplements Do Not Reduce Plaque in Arteries of Postmenopausal Women</a></li></ul><div style="margin-left: 40px;"><p>Soy protein supplements containing isoflavones do not significantly reduce the progression of atherosclerosis (build-up of plaque in the arteries) in postmenopausal women, according to a recent study published in the journal <cite>Stroke</cite>. However, a subgroup analysis of this study showed that soy supplements may benefit women who had experienced menopause within the last 5 years. Isoflavones are compounds similar to the female hormone estrogen and act like estrogen in some tissues. Previous epidemiological and laboratory research has suggested that isoflavones extracted from soybeans may have cardioprotective effects and may be a safe therapeutic alternative to hormone therapy for postmenopausal women. </p></div><ul><li><a href="http://nccam.nih.gov/about/offices/od/director.htm?nav=rss"target="_new" title="Message from the Director: New Directions" >Message from the Director: New Directions</a></li></ul><div style="margin-left: 40px;"><p>The need for careful research on complementary and alternative health practices remains compelling. Tens of millions of Americans are spending $34 billion per year (mostly out-of-pocket) on a variety of complementary approaches, most often without any solid evidence about safety or usefulness.
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Mind and body practices such as meditation and yoga, for example, are generally considered to be safe in healthy people when practiced appropriately. Natural products such as herbal medicines or botanicals are often sold as dietary supplements and are readily available to consumers; however, there is a lot we don�t know about the safety of many of these products, in part because a manufacturer does not have to prove the safety and effectiveness of a dietary supplement before it is available to the public.</p></div><ul><li><a href="http://nccam.nih.gov/health/providers/digest/depression.htm?nav=rss"target="_new" title="Depression and Complementary Health Practices" >Depression and Complementary Health Practices</a></li></ul><div style="margin-left: 40px;"><p>Depression is a medical condition that affects nearly 21 million American adults each year, according to the National Institute of Mental Health. Mood, thoughts, physical health, and behavior all may be affected. Among the common symptoms of depression are persistent sad, anxious, or &#34;empty&#34; feelings; feelings of hopelessness, guilt, and/or worthlessness; restlessness or irritability; fatigue; difficulty concentrating; insomnia; overeating, or loss of appetite; and/or thoughts of suicide.
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