The National Center for Complementary and Alternative Medicine (NCCAM) welcomes six new members to the National Advisory Council for Complementary and Alternative Medicine. The council serves as the principal advisory body to NCCAM, the lead federal agency for research on complementary medicine, and a component of the National Institutes of Health.

Resveratrol is a naturally occurring chemical found in red wine and other plant products and is sometimes sold as a dietary supplement. Recently, a study funded by the National Heart, Lung, and Blood Institute looked at how resveratrol works at the cellular level, identifying how it may provide its health benefits.

Recently, several news outlets have been highlighting research studies of the placebo effect. The placebo response can be defined as the benefit patients receive from a treatment that has no active components. Researchers are using innovative study designs to untangle the complexities of the placebo effect.

Soy protein supplements containing isoflavones do not significantly reduce the progression of atherosclerosis (build-up of plaque in the arteries) in postmenopausal women, according to a recent study published in the journal Stroke. However, a subgroup analysis of this study showed that soy supplements may benefit women who had experienced menopause within the last 5 years. Isoflavones are compounds similar to the female hormone estrogen and act like estrogen in some tissues. Previous epidemiological and laboratory research has suggested that isoflavones extracted from soybeans may have cardioprotective effects and may be a safe therapeutic alternative to hormone therapy for postmenopausal women.

The need for careful research on complementary and alternative health practices remains compelling. Tens of millions of Americans are spending $34 billion per year (mostly out-of-pocket) on a variety of complementary approaches, most often without any solid evidence about safety or usefulness.

The opportunities to make real differences in some very challenging health issues are equally compelling. After a decade of mainly exploratory research across a broad array of interventions, practices, products, and disciplines, emerging scientific evidence points toward the need for more targeted investment in selected complementary approaches.

As with any treatment, it is important to consider safety before using complementary health products and practices. Safety depends on the specific therapy, and each complementary product or practice should be considered on its own.

Mind and body practices such as meditation and yoga, for example, are generally considered to be safe in healthy people when practiced appropriately. Natural products such as herbal medicines or botanicals are often sold as dietary supplements and are readily available to consumers; however, there is a lot we don�t know about the safety of many of these products, in part because a manufacturer does not have to prove the safety and effectiveness of a dietary supplement before it is available to the public.

Depression is a medical condition that affects nearly 21 million American adults each year, according to the National Institute of Mental Health. Mood, thoughts, physical health, and behavior all may be affected. Among the common symptoms of depression are persistent sad, anxious, or "empty" feelings; feelings of hopelessness, guilt, and/or worthlessness; restlessness or irritability; fatigue; difficulty concentrating; insomnia; overeating, or loss of appetite; and/or thoughts of suicide.

Many people with a depressive illness never seek treatment. But the majority, even those with the most severe depression, can get better with treatment. Depression can be treated effectively with conventional medicine, including antidepressants and certain types of psychotherapy.

Some people turn to complementary health products and practices for depression, including the dietary supplement St. John’s wort; however, no complementary approach has been proven effective for the long-term treatment of depression. This issue provides information on "what the science says" about the effects of complementary health products for depression, including the dietary supplements omega-3 fatty acids, St. John’s wort, valerian, as well as other complementary practices such as massage, relaxation techniques, and yoga.

Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut. They are also called "friendly bacteria" or "good bacteria." Probiotics are available to consumers mainly in the form of dietary supplements and foods.

Headaches are one of the most common forms of pain. For some people a headache may be a minor irritation once or twice a year, while others can suffer disabling pain on an almost daily basis. Researchers are studying treatments for different types of headaches, including a number of complementary and alternative medicine (CAM) therapies. This fact sheet provides basic information on headaches, summarizes research on the effectiveness and safety of selected complementary and alternative practices for headaches, and suggests sources for additional information. If you are considering a complementary and alternative therapy for headaches, this information can help you talk to your health care provider about it.

St. John's wort is a plant with yellow flowers whose medicinal uses were first recorded in ancient Greece. The flowering tops of St. John's wort are used to prepare teas, tablets, and capsules containing concentrated extracts. Liquid extracts and topical preparations are also used. Today, St. John's wort is used by some for depression, anxiety, and/or sleep disorders.